Xtane contains exemestane, an oral medication used in the treatment of hormone receptor-positive breast cancer, particularly in postmenopausal women. It is classified as an aromatase inhibitor, specifically a steroidal aromatase inactivator, which helps reduce estrogen levels in the body. Lowering estrogen is a key part of hormone therapy for certain types of breast cancer, as estrogen can promote the growth of these tumors. Xtane is typically used after other hormonal therapies or as part of a long-term treatment plan.

Mechanism of Action

Exemestane works by irreversibly binding to and disabling the aromatase enzyme, which is responsible for converting androgens into estrogens in postmenopausal women. By inactivating this enzyme, Xtane effectively lowers estrogen levels, thereby limiting the stimulation of estrogen-dependent cancer cells. This irreversible action distinguishes it from some other aromatase inhibitors and contributes to its effectiveness in long-term therapy.

Uses

Xtane is commonly used for:

• Adjuvant treatment of early-stage, hormone receptor-positive breast cancer after initial treatment with tamoxifen

• Treatment of advanced or metastatic breast cancer in postmenopausal women whose disease has progressed following other hormone therapy

• It may also be used off-label in managing estrogen-sensitive conditions under specialist guidance

  Adverse Effects

  Common side effects

  • Hot flashes

  • Joint or bone pain

  • Fatigue

  • Increased sweating

  • Nausea