Cazanat 60 mg contains cabozantinib, a targeted oral cancer medicine used to manage certain advanced cancers. It is especially effective in cancers that are resistant to earlier treatments. Belonging to a class of drugs known as tyrosine kinase inhibitors, cabozantinib is designed to interfere with cancer cell growth and the formation of blood vessels that feed tumors. Its use offers many patients a vital option in later stages of their cancer journey.

Mechanism of Action

Cabozantinib works by blocking multiple enzymes called tyrosine kinases that are involved in cancer cell growth, spread, and blood vessel formation. Specifically, it targets receptors like MET, VEGFR, and AXL which are often overactive in cancer cells. By blocking these pathways, cabozantinib helps to slow down the tumor’s progression, cut off its blood supply, and reduce the chances of further spread. This multi-targeted action is why it can be effective in cancers that have not responded to other treatments.

Uses

Cazanat is used in the treatment of:

• Advanced Renal Cell Carcinoma (Kidney cancer)
  In patients who have received prior therapy

• Hepatocellular Carcinoma (Liver cancer)
  In patients who have been previously treated with sorafenib

• Medullary Thyroid Carcinoma
  Especially when the cancer is metastatic or cannot be surgically removed

  Adverse Effects

  Common side effects include

  • Diarrhoea and loss of appetite

  • Fatigue or weakness

  • Nausea and vomiting

  • Mouth sores

  • High blood pressure

  • Changes in hair colour or texture