Oxaliptin 50 mg contains oxaliplatin, a chemotherapy medicine used primarily to treat cancers of the colon and rectum. It belongs to a group of drugs known as platinum-based antineoplastics and is typically given in combination with other chemotherapy agents like fluorouracil and leucovorin.

Oxaliplatin is delivered via intravenous infusion and is an important part of the FOLFOX regimen, a widely used combination in colorectal cancer treatment. Its role is vital in both curative and palliative settings, helping reduce the risk of recurrence after surgery or controlling cancer progression in advanced stages.

Mechanism of Action

Oxaliplatin works by binding to the DNA in cancer cells and forming cross-links. These cross-links interfere with the normal function of DNA, particularly its ability to replicate and repair. As a result, cancer cells are unable to divide properly and eventually die.

Unlike older platinum drugs, oxaliplatin forms different types of DNA adducts that may be effective even in cancers that have become resistant to other treatments. It is considered more potent and has a broader spectrum of action when combined with fluorouracil-based therapy.

Uses

Oxaliptin is used mainly in the treatment of:

• Colorectal cancer, in both early-stage (after surgery) and advanced metastatic stages

• Often part of the FOLFOX regimen, which includes fluorouracil and leucovorin

• It may also be used off-label in other gastrointestinal cancers when prescribed by an oncologist

  Adverse Effects

  While Oxaliptin plays an important role in cancer treatment, like all chemotherapy, it may cause side effects. These can range from mild to serious and may vary from person to person.

  Common Side Effects

  • Numbness or tingling, particularly in the hands and feet (peripheral neuropathy)

  • Sensitivity to cold, which may worsen nerve symptoms

  • Nausea, vomiting, and diarrhea

  • Fatigue or tiredness

  • Loss of appetite

  • Low blood counts, which can lead to infections, bleeding, or anemia