Innogem contains gemcitabine, a chemotherapy medication that is used to treat several types of cancer. It is classified as an antimetabolite, which means it interferes with the normal function of DNA in cancer cells, ultimately stopping their growth. Innogem is typically given through intravenous infusion and may be used alone or in combination with other chemotherapy agents.

Gemcitabine has become a key part of treatment protocols for cancers that are difficult to treat, including pancreatic, lung, bladder, and breast cancers. Its effectiveness, along with a relatively manageable side effect profile, makes it a commonly chosen agent in oncology.

Mechanism of Action

Gemcitabine works by mimicking the building blocks of DNA. During the process of DNA replication, cancer cells mistakenly incorporate gemcitabine into their genetic material. This causes the DNA chain to stop growing and prevents the cell from dividing properly.

Additionally, gemcitabine also inhibits an enzyme responsible for DNA synthesis, leading to reduced production of genetic material. These combined actions result in the death of cancer cells, especially those that are rapidly dividing.

Uses

Innogem (gemcitabine) is used in the treatment of a variety of cancers, including:

• Pancreatic cancer, both as a primary treatment and in advanced cases

• Non-small cell lung cancer, often in combination with other drugs

• Bladder cancer, particularly when surgery or radiation is not suitable

• Breast cancer, especially after the failure of prior treatments

• Ovarian cancer, frequently in patients who have relapsed

• Biliary tract cancers, such as cholangiocarcinoma, in certain protocols

  Adverse Effects

  Gemcitabine is generally well tolerated, but like all chemotherapy medications, it can affect both cancerous and some healthy cells.

  Common Side Effects

  • Low blood cell counts, which may increase the risk of infections, anemia, or bleeding

  • Fatigue or general weakness

  • Nausea and vomiting, usually manageable with supportive medication

  • Flu-like symptoms, such as fever and chills

  • Loss of appetite and weight loss

  • Skin rash or itching