BDTaxel 300 mg contains paclitaxel, a chemotherapy medication that plays a key role in the treatment of various cancers. Derived from the bark of the Pacific yew tree, paclitaxel is classified as a taxane and works by disrupting the normal function of cancer cell division. It is often used as part of combination chemotherapy protocols and is typically given via intravenous infusion under medical supervision.
BDTaxel is used when the goal is to either shrink tumors before surgery or prevent recurrence after primary treatment. Its wide spectrum of activity makes it valuable in managing solid tumors in different stages.
Mechanism of Action
Paclitaxel works by stabilising microtubules, which are essential components of a cell’s internal skeleton and division machinery. Normally, microtubules grow and shrink during cell division. Paclitaxel binds to tubulin and prevents microtubules from disassembling, which is a necessary step in cell division.
This action halts the cell cycle in the mitotic phase, eventually leading to cell death. Since cancer cells divide more rapidly than normal cells, they are especially sensitive to this disruption.
Uses
BDTaxel is used in the treatment of a variety of solid tumors, including:
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Breast cancer, particularly in metastatic settings or after failure of standard treatment
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Ovarian cancer, both as first-line and recurrent disease therapy
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Non-small cell lung cancer, in combination with other agents
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Kaposi’s sarcoma in patients with HIV, though less commonly today
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Other off-label uses include prostate, bladder, and esophageal cancers
Adverse Effects
Like most chemotherapy drugs, paclitaxel can affect both cancerous and healthy rapidly dividing cells. This can lead to a range of side effects, some of which may require supportive treatments or dose adjustments.
Common Side Effects
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Hair loss
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Fatigue
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Nausea and vomiting
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Low blood counts, especially white cells
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Mild joint and muscle pain
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Peripheral neuropathy, often presenting as tingling or numbness in hands and feet
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