Leugard 11.25 mg contains leuprorelin acetate, a synthetic hormone used in the treatment of hormone-sensitive conditions such as prostate cancer, breast cancer, and endometriosis. It belongs to a class of drugs known as gonadotropin-releasing hormone agonists. Leugard works by regulating hormone levels in the body and is typically given as a depot injection that slowly releases the medicine over several weeks. This long-acting formulation is especially beneficial for patients requiring sustained hormone suppression.

Mechanism of Action

Leuprorelin acetate acts by initially stimulating, then subsequently suppressing, the pituitary gland’s release of luteinizing hormone and follicle-stimulating hormone. This leads to a decrease in sex hormones such as testosterone in males and oestrogen in females. After the initial surge, the continuous stimulation causes the body to stop producing these hormones, effectively creating a temporary and reversible hormone suppression. This mechanism is particularly helpful in slowing down the progression of hormone-dependent cancers and conditions.

Uses

Leugard 11.25 mg is used for a variety of medical conditions where hormone suppression is beneficial:

• Prostate cancer: To reduce testosterone levels and slow cancer growth

• Breast cancer: In hormone-receptor-positive cases, especially in premenopausal women

• Endometriosis: To reduce oestrogen production and alleviate associated pain

• Uterine fibroids: Often used prior to surgery to reduce fibroid size

• Central precocious puberty: To delay early puberty in children

  Adverse Effects

  Because Leugard alters the normal hormonal balance in the body, it may lead to a range of side effects. Some of these are temporary and tend to settle as the body adjusts to the new hormone levels.

  Common Side Effects

  • Hot flashes or flushing

  • Sweating, especially at night

  • Reduced libido and sexual function

  • Mood swings or emotional changes

  • Vaginal dryness in women or breast tenderness in men

  • Injection site reactions such as redness or pain