Adrosal 50 mg contains doxorubicin, a well-established chemotherapy medication belonging to the class of anthracyclines. Often referred to as the “red devil” due to its bright red color, doxorubicin is a potent anticancer drug used in the treatment of various cancers. It is typically given as an intravenous infusion, and its use is guided by strict dosing protocols due to its potential impact on the heart.

Doxorubicin is known for its broad spectrum of activity and forms part of many standard chemotherapy regimens. Despite being a powerful agent, it is often used in combination with other drugs to improve efficacy and reduce resistance.

Mechanism of Action

Doxorubicin works by interfering with the DNA inside cancer cells. It binds to DNA and blocks the action of an enzyme called topoisomerase II, which is essential for cell replication. It also generates free radicals, which cause further damage to cellular structures.

These combined effects lead to irreparable damage to the DNA, causing the cancer cells to stop growing and eventually die. However, because this mechanism can also affect normal rapidly dividing cells, side effects can occur.

Uses

Adrosal (doxorubicin) is widely used in the treatment of many cancers, both solid tumors and blood-related cancers. Some of the most common indications include:

• Breast cancer, often as part of combination regimens

• Lymphomas, including Hodgkin and non-Hodgkin types

• Leukemias, particularly acute lymphoblastic leukemia

• Ovarian and bladder cancer

• Sarcomas, including soft tissue and bone sarcomas

• Lung cancer, in selected regimens

  Adverse Effects

  Doxorubicin is effective but comes with a distinct profile of side effects, many of which are predictable and manageable with appropriate care.

  Common Side Effects

  • Nausea and vomiting

  • Hair loss

  • Fatigue

  • Low white and red blood cell counts

  • Mouth sores or inflammation

  • Skin darkening or nail discoloration