Luprohal contains leuprolide acetate, a synthetic form of a naturally occurring hormone used to manage hormone-dependent conditions. It is commonly prescribed in the treatment of prostate cancer, endometriosis, uterine fibroids, and precocious puberty. As a long-acting injection, it allows for sustained control over hormone levels in the body.

Luprohal works by targeting and regulating the hormones that influence reproductive organs, making it an effective option in cases where reducing hormone stimulation is key to managing disease progression or symptoms.

Mechanism of Action

Leuprolide acetate is classified as a gonadotropin-releasing hormone agonist, or GnRH agonist. Initially, it stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a temporary rise in sex hormones like testosterone or estrogen. However, with continued use, it desensitises the pituitary gland, leading to suppressed production of these hormones.

This suppression is especially useful in hormone-sensitive cancers and disorders, where reducing estrogen or testosterone levels can help control the disease.

Uses

Luprohal is used in a variety of hormone-driven conditions, including:

• Prostate cancer – to reduce testosterone levels and slow cancer growth

• Endometriosis – to relieve pain by lowering estrogen levels

• Uterine fibroids – to shrink fibroids and reduce symptoms like heavy bleeding

• Central precocious puberty – to delay early puberty in children

• Assisted reproduction protocols – to control ovulation timing

  Adverse Effects

  Like many hormonal therapies, Luprohal may cause temporary or ongoing side effects, especially in the early phase of treatment when hormone levels briefly surge before dropping.

  Common Side Effects

  • Hot flashes or sweating

  • Mood swings or emotional changes

  • Headaches

  • Decreased libido

  • Vaginal dryness (in females)

  • Fatigue or weakness