Z-Texel 60 mg contains cabazitaxel, an advanced chemotherapy medication belonging to the taxane class of anti-cancer agents. It is designed to treat advanced prostate cancer, particularly in patients who have not responded well to previous treatments such as docetaxel.

This formulation is administered intravenously by a trained healthcare provider and is often used in combination with other supportive medications to help reduce side effects and improve outcomes.

Mechanism of Action

Cabazitaxel works by interfering with the microtubule structures inside cancer cells. Microtubules are part of the cell’s internal framework and are essential for cell division.

Cabazitaxel binds to these structures and stabilizes them in a way that prevents the cancer cells from completing the process of division. As a result, cancer cells are unable to multiply and eventually die. Unlike earlier taxanes, cabazitaxel has been specially developed to overcome resistance in cancer cells that have stopped responding to other similar drugs.

Uses

Z-Texel 60 mg is primarily used in the treatment of:

• Metastatic castration-resistant prostate cancer (mCRPC), especially in patients who have progressed after treatment with docetaxel-based chemotherapy.

It is usually administered along with prednisone or prednisolone to help reduce inflammation and improve overall response.

Adverse Effects

Like other chemotherapy medications, cabazitaxel affects not only cancer cells but also normal cells, especially those that divide quickly. This can lead to side effects, some of which require close monitoring and management by the healthcare team.

Common Side Effects

• Fatigue or weakness

• Low white blood cell count (neutropenia), increasing infection risk

• Anemia or low red blood cell count

• Nausea, vomiting, or diarrhea

• Hair thinning or hair loss

• Loss of appetite

• Back pain or joint pain