Jakura contains tofacitinib, an oral medication primarily used to manage autoimmune conditions where the body’s immune system mistakenly attacks its own tissues. It is a Janus kinase (JAK) inhibitor, which helps reduce inflammation and symptoms in disorders such as rheumatoid arthritis and ulcerative colitis.

Tofacitinib is often prescribed when patients do not respond well to conventional therapies or need an alternative to injectable treatments. It offers a convenient oral option for long-term disease control under the supervision of a healthcare provider.

Mechanism of Action

Tofacitinib works by inhibiting a group of enzymes known as Janus kinases (JAKs), which play a key role in the signalling pathways that regulate immune function and inflammation. These enzymes help transmit signals from outside the cell to the cell nucleus, influencing the activity of immune cells.

By blocking JAK activity, tofacitinib reduces the production of inflammatory substances and prevents the overactive immune response that causes damage in autoimmune diseases. This helps relieve symptoms, slows disease progression, and improves quality of life for patients.

Uses

Jakura (tofacitinib) is approved and commonly used for the treatment of several inflammatory and autoimmune conditions, including:

• Rheumatoid arthritis in adults who have not responded well to other disease-modifying anti-rheumatic drugs

• Psoriatic arthritis, especially when traditional treatments are inadequate

• Ulcerative colitis, a chronic inflammatory condition of the colon

• Juvenile idiopathic arthritis, in selected cases with physician guidance

• Ankylosing spondylitis, in certain regions where approved for this use

  Adverse Effects

  While tofacitinib is effective for controlling inflammation, it can also suppress the immune system, increasing the risk of certain side effects. Monitoring and regular follow-ups are essential during treatment.

  Common Side Effects

  • Headache or mild gastrointestinal discomfort

  • Increased cholesterol levels

  • Upper respiratory tract infections

  • High blood pressure

  • Fatigue