Thalitero 100 mg contains thalidomide, a medication with a complex history and powerful therapeutic potential. Once known for its harmful effects in pregnancy, thalidomide is now carefully used under strict medical guidance to treat certain cancers and inflammatory conditions. It is particularly valued in the treatment of multiple myeloma and erythema nodosum leprosum, a painful skin complication of leprosy.

Thalitero is typically used in adults under close supervision due to its potent effects and specific safety precautions. It is often part of a broader treatment plan that may include steroids or chemotherapy agents.

Mechanism of Action

Thalidomide acts through several mechanisms. It has immunomodulatory, anti-inflammatory, and anti-angiogenic properties, meaning it helps regulate the immune response, reduce inflammation, and prevent the growth of new blood vessels that tumors rely on.

Specifically, thalidomide inhibits the release of certain cytokines like tumor necrosis factor alpha, which play a role in inflammation and immune activity. It also affects the growth of abnormal cells by limiting their blood supply and enhancing immune surveillance.

These actions contribute to its effectiveness in reducing cancer cell survival and managing inflammatory symptoms.

Uses

Thalitero is approved and widely used for:

• Multiple myeloma, particularly in combination with dexamethasone or other agents to improve survival in newly diagnosed or relapsed cases

• Erythema nodosum leprosum, an inflammatory complication of leprosy, where it helps reduce painful skin lesions and systemic inflammation

• It may also be used off-label in selected cancers or autoimmune conditions under specialist care

  Adverse Effects

  While thalidomide can be highly effective, it must be used cautiously due to the risk of serious side effects. All patients are monitored closely, and women of childbearing age must follow strict pregnancy prevention protocols.

  Common Side Effects

  • Drowsiness or fatigue

  • Constipation

  • Peripheral neuropathy, which may cause tingling, numbness, or weakness in hands and feet

  • Skin rash

  • Dizziness