Lomoother 40 mg contains lomustine, an oral chemotherapy medication that belongs to the class of alkylating agents. It is primarily used in the treatment of certain types of brain tumors and lymphomas. Due to its ability to cross the blood-brain barrier, lomustine is especially valuable in managing central nervous system malignancies.

Lomustine is typically given as part of a cyclic treatment plan and not taken daily. Its long-lasting effects allow for intervals between doses to let the body recover, especially the bone marrow.

Mechanism of Action

Lomustine works by interfering with the DNA of cancer cells. It adds alkyl groups to the DNA strands, causing cross-links that prevent the cells from replicating properly. This action leads to the eventual death of cancer cells.

Unlike many other chemotherapy drugs, lomustine is lipid-soluble, which enables it to penetrate the central nervous system more effectively. This makes it particularly useful for treating brain tumors.

Uses

Lomoother is commonly used for:

• Brain tumors, including glioblastoma multiforme and astrocytomas, often in combination with other treatments like surgery and radiation

• Hodgkin’s lymphoma, especially in patients who have relapsed or not responded to first-line therapies

• Occasionally used in other types of cancers when standard treatments are not effective

  Adverse Effects

  Lomustine is effective but can also cause notable side effects, some of which may be serious. Regular monitoring is essential to manage these risks.

  Common Side Effects

  • Nausea and vomiting

  • Fatigue

  • Loss of appetite

  • Temporary hair loss