LANIB 250 contains lapatinib, an oral targeted therapy used primarily in the treatment of certain types of advanced or metastatic breast cancer. It is most effective in patients whose cancer cells overexpress the HER2 protein, a receptor that promotes aggressive tumor growth. Lapatinib is usually prescribed in combination with other medications like capecitabine or letrozole and is taken by mouth as part of long-term cancer management. It is often used in patients who have already received other HER2-targeted therapies and have shown disease progression. Mechanism of Action
Lapatinib works by blocking the activity of two proteins on the surface of cancer cells: HER2 and EGFR, both of which are involved in the signaling pathways that drive cell growth and division. These proteins are part of a family of enzymes known as tyrosine kinases. By inhibiting both HER2 and EGFR, lapatinib disrupts the internal signals that cancer cells use to grow and spread. This dual inhibition helps to slow down or stop tumor growth, particularly in HER2-positive cancers where this pathway is especially active.

Uses

LANIB 250 is mainly used in the treatment of advanced or metastatic breast cancer, especially in cases that are HER2-positive. It is often combined with capecitabine for patients who have previously been treated with trastuzumab and chemotherapy. In hormone receptor-positive breast cancer, it may also be used alongside letrozole to delay disease progression. The treatment is intended for patients who have not responded to other lines of therapy and is typically part of a long-term treatment plan.

Adverse Effects
Like all cancer treatments, lapatinib may cause side effects, although not everyone will experience them. Common side effects include diarrhea, nausea, vomiting, rash, tiredness, and hand-foot syndrome. Some people may also experience a decrease in appetite or mild heart rhythm changes. More serious side effects include liver function abnormalities and, in rare cases, heart issues such as decreased heart pumping ability. Monitoring through blood tests and heart evaluations is important during therapy. If side effects are severe, your doctor may adjust the dose or temporarily stop treatment to allow recovery.