Epintris contains epirubicin, a chemotherapy medicine that belongs to the anthracycline class of anticancer drugs. It is commonly used in the treatment of various solid tumors, especially breast cancer. Epirubicin is structurally related to doxorubicin but is designed to have a better safety profile with reduced heart toxicity.

Mechanism of Action:

Epirubicin works by interfering with the DNA of cancer cells, stopping them from multiplying and eventually leading to their death. It acts through several mechanisms:

• It inserts itself between DNA strands, preventing proper DNA replication and transcription

• It inhibits the enzyme topoisomerase II, which is crucial for DNA repair and replication

• It generates free radicals, which further damage the DNA and cell membranes

  Uses:

  Epintris is used as a part of chemotherapy regimens for various cancers, including:

  • Breast cancer (commonly used after surgery to prevent recurrence)

  • Ovarian cancer

  • Stomach cancer

  • Lung cancer

  • Bladder cancer (in intravesical form, directly into the bladder)

    Adverse Effects:

    Like most chemotherapy drugs, epirubicin affects both cancerous and some healthy rapidly growing cells, leading to a range of side effects.

    Common side effects:

    • Nausea and vomiting

    • Hair loss

    • Fatigue and weakness

    • Mouth sores

    • Low blood cell counts, increasing the risk of infections, bleeding, or anemia