Neukine contains filgrastim, a lab-made version of a natural protein called granulocyte-colony stimulating factor (G-CSF). It is used to help the body produce more white blood cells, especially neutrophils, which are crucial for fighting infections. Neukine is commonly given as an injection to cancer patients who have weakened immune systems due to chemotherapy or bone marrow suppression.

Mechanism of Action:

Filgrastim works by:

• Stimulating the bone marrow to produce more neutrophils

• Helping these cells mature more quickly and function properly

• Reducing the time the patient’s white blood cell count stays low after chemotherapy

  Uses:

  Neukine is prescribed for:

  • Cancer patients receiving chemotherapy, to prevent or treat neutropenia (low neutrophil count)

  • Patients undergoing bone marrow transplant or stem cell transplant

  • People with severe chronic neutropenia

  • Mobilising stem cells before collection for transplant

  • HIV/AIDS-related neutropenia, in some cases

    Adverse Effects:

    While generally well tolerated, Neukine can cause some side effects:

    Common side effects:

    • Bone pain or muscle pain

    • Injection site redness or swelling

    • Fatigue

    • Headache

    • Nausea