Nicoduce 48 mg contains Nicorandil, a medication used to manage angina pectoris, which is chest pain caused by reduced blood flow to the heart. It belongs to a class of medicines known as vasodilators. Nicorandil acts as both a nitrate-like drug and a potassium channel opener, which helps relax and widen blood vessels to improve blood supply to the heart muscles.

Mechanism of Action:

Nicorandil works through two complementary actions:

1. Nitrate-like effect – It donates nitric oxide, which relaxes the smooth muscles in blood vessels, especially in the heart, reducing the heart’s oxygen demand.

2. Potassium channel opening – It opens ATP-sensitive potassium channels in vascular smooth muscle, causing further relaxation and vasodilation of both arteries and veins.

   Uses:

   • Prevention and long-term management of chronic stable angina (chest pain)

   • Can be used in patients who do not tolerate beta-blockers or calcium channel blockers well

     Adverse Effects:

     Common side effects:

     • Headache (especially at the beginning of treatment due to blood vessel dilation)

     • Dizziness or lightheadedness

     • Nausea

     • Flushing or feeling warm