Apigat 5 mg contains Apixaban, an oral anticoagulant used to prevent and treat blood clots. It belongs to a class of medications known as direct oral anticoagulants (DOACs) and is commonly prescribed to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation, as well as for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE)

Mechanism of Action:
Apixaban works by selectively inhibiting Factor Xa, a key enzyme in the blood coagulation cascade:

• By blocking Factor Xa, apixaban prevents the conversion of prothrombin to thrombin, which is essential for the formation of a blood clot.

• This reduces the formation of fibrin, the protein that stabilizes blood clots.

• The inhibition is direct and reversible, and it does not require a cofactor like antithrombin.

  Uses:
  Apigat 5 mg is used for:

  • Stroke and systemic embolism prevention in patients with non-valvular atrial fibrillation

  • Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE)

  • Prevention of recurrent DVT and PE after initial therapy

  • Prophylaxis of DVT following hip or knee replacement surgery

    Adverse Effects:
    While apixaban is effective, it can have side effects that require monitoring:

    Common side effects:

    • Bleeding (including nosebleeds, bruising, or gastrointestinal bleeding)

    • Nausea or upset stomach

    Serious side effects:

    • Major bleeding (such as brain hemorrhage or prolonged bleeding from wounds)

    • Allergic reactions, which may include rash, itching, or swelling

    • Anemia, which can cause fatigue or weakness