Fucidin is a topical antibiotic ointment that contains sodium fusidate, a powerful antimicrobial agent derived from the fungus Fusidium coccineum. It is primarily used to treat skin infections caused by bacteria, particularly Staphylococcus aureus, including strains that may be resistant to other antibiotics.

Mechanism of Action:
Sodium fusidate works by inhibiting bacterial protein synthesis:

• It binds to elongation factor G (EF-G) on the bacterial ribosome, a critical component in the protein-making process.

• This binding prevents bacteria from producing the proteins they need to grow and multiply.

• As a result, bacterial growth is halted, and the immune system can clear the infection more effectively.

  Uses:
  Fucidin ointment is commonly used for:

  • Impetigo, a contagious skin infection often seen in children

  • Infected eczema or dermatitis

  • Folliculitis and boils

  • Infected wounds, cuts, or surgical incisions

  • Minor skin infections caused by staphylococcal or streptococcal bacteria

    Adverse Effects:
    Fucidin ointment is generally well-tolerated, but some people may experience:

    • Skin irritation, redness, or itching at the application site

    • Allergic skin reactions, including rash or swelling in rare cases

    • Contact dermatitis, especially with prolonged use

    • Overuse may lead to resistance or reduce the drug’s effectiveness over time