Pantotec 40 mg contains Pantoprazole, a proton pump inhibitor (PPI) used to treat conditions caused by excessive gastric acid. It helps soothe symptoms such as heartburn, acid reflux, and promote healing in peptic ulcer disease and erosive esophagitis.

Mechanism of Action

Pantoprazole works by binding irreversibly to the H⁺/K⁺-ATPase enzyme (the proton pump) in the stomach lining. This action blocks the final step of acid secretion, substantially reducing gastric acid and allowing irritation and ulcerated tissue to heal.

Uses

Pantotec 40 mg is used for:

• Gastroesophageal reflux disease (GERD) and erosive reflux esophagitis

• Peptic ulcer disease, including NSAID-associated ulcers

• Zollinger–Ellison syndrome, a rare condition with excessive acid production

• Assisting Helicobacter pylori eradication as part of combination therapy

  Adverse Effects

  Common (mild and typically temporary):

  • Headache, dizziness, and joint pain

  • Gastrointestinal discomfort: nausea, diarrhea, flatulence, stomach pain, vomiting

    Less frequent or severe:

    • Low magnesium levels (hypomagnesemia), which may cause fatigue, muscle twitches, shakiness, irregular heartbeat

    • Vitamin B12 deficiency and anemia with long-term use, leading to tiredness, mouth ulcers, or pins and needles sensation

    • Increased risk of bone fractures, especially with over one year of continuous use

    • Risk of infections such as Clostridioides difficile or pneumonia due to decreased stomach acidity

    • Rare reactions: acute interstitial nephritis (kidney inflammation), lupus-like syndrome, serious skin reactions (e.g. Stevens–Johnson syndrome), and low blood counts