Pentasa 500 mg contains Mesalazine (also known as mesalamine), an anti-inflammatory drug used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease. It helps to reduce inflammation in the lining of the intestines and relieve symptoms like abdominal pain, diarrhea, and bleeding.

Mechanism of Action
Mesalazine works by inhibiting the production of inflammatory chemicals, particularly prostaglandins and leukotrienes, in the lining of the colon. It acts locally at the site of inflammation in the gut rather than being absorbed into the bloodstream, helping to control inflammation and maintain remission in chronic bowel disease.

Uses
Pentasa 500 mg is used for:

• Ulcerative colitis, both in active flare-ups and for maintenance therapy

• Crohn’s disease, especially when affecting the colon

• Reducing the frequency of relapses in inflammatory bowel conditions

  Adverse Effects
  Mesalazine is usually well tolerated, but some patients may experience:

  • Nausea, abdominal pain, or flatulence

  • Headache or dizziness

  • In rare cases, pancreatitis, kidney function impairment, or allergic reactions

  • Rash or fever may occur occasionally

  • Very rarely, blood disorders like low white cell count may develop