Pulmonext 10 mg contains Ambrisentan, an endothelin receptor antagonist prescribed for pulmonary arterial hypertension (PAH)—a condition in which the blood pressure in the lungs’ arteries is elevated, burdening the right side of the heart. By easing resistance in pulmonary vessels, the drug relieves strain on the heart and helps improve overall quality of life.

Mechanism of Action

Ambrisentan works by blocking endothelin receptors, preventing endothelin (a chemical naturally produced in the body) from causing blood vessels to constrict. By widening the pulmonary arteries, it reduces pulmonary arterial pressure and eases blood flow from the heart to the lungs

Uses

Pulmonext 10 mg is used for:

• Treating pulmonary arterial hypertension (PAH) in adults, helping delay disease progression and improve exercise capacity

  Adverse Effects

  Common:

  • Headache, dizziness, nasal congestion, flushing, fatigue, and swelling in legs or ankles (peripheral edema)

  • Palpitations, shortness of breath, diarrhea

  Serious (requires immediate medical attention):

  • Liver toxicity or elevated liver enzymes—watch for signs like nausea, loss of appetite, dark urine, or jaundice

  • Fluid retention that may worsen heart failure and anemia (low red blood cell count)

  • Decreased sperm count in men; potential for birth defects if taken during pregnancy—contraindicated in pregnant women; effective contraception advised during treatment and for one month after stopping it