Trulicity is a once-weekly injectable medication used in the treatment of type 2 diabetes mellitus. It contains dulaglutide, which belongs to a class of drugs called GLP-1 receptor agonists. Trulicity is used to improve blood sugar control in adults, and it may also reduce the risk of major cardiovascular events in individuals with heart disease. It is typically prescribed when lifestyle changes and other oral medications are not sufficient to control blood glucose levels.

Mechanism of Action
Dulaglutide mimics the action of a natural hormone called GLP-1 (glucagon-like peptide-1), which helps regulate blood sugar levels. It works through multiple pathways:

• It stimulates the pancreas to release insulin in response to high blood sugar

• It reduces the amount of glucagon (a hormone that raises blood sugar) produced by the liver

• It slows down gastric emptying, which helps prevent spikes in blood sugar after meals

• It may also reduce appetite, leading to modest weight loss in some individuals

  Uses
  Trulicity is used for:

  • Managing blood glucose levels in adults with type 2 diabetes mellitus

  • Reducing the risk of heart attack, stroke, or cardiovascular death in people with both type 2 diabetes and existing heart disease

  • Helping patients who have difficulty adhering to daily medications, as it is administered only once per week

    Adverse Effects
    Trulicity is generally well tolerated, but some people may experience side effects.

    Common side effects:

    • Nausea, especially when first starting treatment

    • Diarrhoea

    • Vomiting

    • Abdominal discomfort

    • Decreased appetite