Xapavir 50 mg contains dolutegravir, an antiretroviral medicine used in the management of HIV-1 infection. It is a part of a class of drugs known as integrase strand transfer inhibitors. Xapavir is widely used in first-line therapy for HIV due to its strong antiviral activity, high barrier to resistance, and once-daily dosing. It plays a crucial role in improving the quality of life and life expectancy of people living with HIV.

Mechanism of Action
Dolutegravir works by blocking an enzyme called HIV integrase. This enzyme is essential for the virus to replicate and integrate its genetic material into the DNA of human cells. By inhibiting this enzyme, dolutegravir prevents the virus from multiplying and stops the progression of the infection. This helps reduce the viral load in the body and improves immune system function over time.

Uses
Xapavir 50 mg is used for:

• Treatment of HIV-1 infection in adults and adolescents above a certain weight threshold, usually in combination with other antiretroviral agents

• First-line therapy in newly diagnosed patients due to its effectiveness and low risk of resistance

• Switch therapy for patients already on antiretroviral treatment, to simplify their regimen or reduce side effects

  Adverse Effects

  Common side effects include:

  • Headache

  • Insomnia

  • Tiredness or fatigue

  • Diarrhoea or nausea