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Zidolam

Zidolam

Zidolam is a combination antiretroviral medicine used in the treatment of Human Immunodeficiency Virus type 1 (HIV-1) infection. It contains two active ingredients: zidovudine and lamivudine, both of which belong to a class of drugs called nucleoside reverse transcriptase inhibitors. Zidolam is used as part of a combination therapy to manage HIV infection, reduce viral load, and help restore and maintain immune function.

Uses:
Zidolam is used for:

  • The treatment of HIV-1 infection in adults and children as part of combination antiretroviral therapy.

  • It is often prescribed in combination with other antiretroviral medicines to improve effectiveness and reduce the risk of drug resistance.

Mechanism of Action:
Zidolam works by interfering with the ability of the HIV virus to replicate in the body:

  • Zidovudine is one of the earliest antiretroviral drugs and mimics a natural building block of DNA. It gets incorporated into the viral DNA chain during replication, leading to early termination and preventing further virus production.

  • Lamivudine works similarly by blocking the reverse transcriptase enzyme that HIV uses to convert its RNA into DNA, a key step in its replication cycle.

Adverse Effects:
Zidolam is generally effective, but some individuals may experience side effects. Common ones include:

  • Headache

  • Nausea

  • Tiredness

  • Muscle pain

  • Digestive discomfort

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